Back to Search
Start Over
A Single Bout of High-Intensity Interval Training Reduces Awareness of Subsequent Hypoglycemia in Patients With Type 1 Diabetes.
- Source :
- Diabetes; Jul2017, Vol. 66 Issue 7, p1990-1998, 9p
- Publication Year :
- 2017
-
Abstract
- High-intensity interval training (HIIT) has gained increasing popularity in patients with diabetes. HIIT acutely increases plasma lactate levels. This may be important, since the administration of lactate during hypoglycemia suppresses symptoms and counterregulation while preserving cognitive function. We tested the hypothesis that, in the short term, HIIT reduces awareness of hypoglycemia and attenuates hypoglycemia-induced cognitive dysfunction. In a randomized crossover trial, patients with type 1 diabetes and normal awareness of hypoglycemia (NAH), patients with impaired awareness of hypoglycemia (IAH), and healthy participants (n = 10 per group) underwent a hyperinsulinemic-hypoglycemic (2.6 mmol/L) clamp, either after a HIIT session or after seated rest. Compared with rest, HIIT reduced symptoms of hypoglycemia in patients with NAH but not in healthy participants or patients with IAH. HIIT attenuated hypoglycemia-induced cognitive dysfunction, which was mainly driven by changes in the NAH subgroup. HIIT suppressed cortisol and growth hormone responses, but not catecholamine responses to hypoglycemia. The present findings demonstrate that a single HIIT session rapidly reduces awareness of subsequent hypoglycemia in patients with type 1 diabetes and NAH, but does not in patients with IAH, and attenuates hypoglycemia-induced cognitive dysfunction. The role of exercise-induced lactate in mediating these effects, potentially serving as an alternative fuel for the brain, should be further explored. [ABSTRACT FROM AUTHOR]
- Subjects :
- INTERVAL training
DIABETES
CARBOHYDRATE intolerance
HYPOGLYCEMIA
COGNITIVE ability
CATECHOLAMINES
COGNITION
COMPARATIVE studies
CROSSOVER trials
HYDROCORTISONE
HYPOGLYCEMIC agents
INSULIN
TYPE 1 diabetes
LACTIC acid
NEUROPSYCHOLOGICAL tests
RESEARCH methodology
MEDICAL cooperation
RESEARCH
EVALUATION research
HUMAN growth hormone
RANDOMIZED controlled trials
CASE-control method
GLUCOSE clamp technique
DISEASE complications
PSYCHOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 00121797
- Volume :
- 66
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Diabetes
- Publication Type :
- Academic Journal
- Accession number :
- 123766541
- Full Text :
- https://doi.org/10.2337/db16-1535