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Chiral N,N′-dioxide/Co(ii)-promoted asymmetric 1,3-dipolar cycloaddition of nitrones with methyleneindolinones.
- Source :
- Chemical Communications; 7/18/2017, Vol. 53 Issue 56, p7925-7928, 4p
- Publication Year :
- 2017
-
Abstract
- A chiral N,N′-dioxide/Co(BF<subscript>4</subscript>)<subscript>2</subscript>·6H<subscript>2</subscript>O complex catalytic system has been developed to efficiently catalyze the asymmetric 1,3-dipolar cycloaddition of nitrones with methyleneindolinones. The corresponding chiral multisubstituted spiroisoxazolidines with three contiguous quaternary–tertiary stereocenters were obtained in moderate to high yields with excellent dr and ee values (up to 97% yield, >19 : 1 dr and 98% ee). [ABSTRACT FROM AUTHOR]
- Subjects :
- RING formation (Chemistry)
NITRONES
INDOLINONE
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 53
- Issue :
- 56
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 124057213
- Full Text :
- https://doi.org/10.1039/c7cc03575f