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Cascade reaction of alkynols with 1-(2-aminophenyl)prop-2-ynols to form a fused 5,5,6-tricyclic system: formation of four bonds in a single reaction.
- Source :
- Chemical Communications; 8/7/2017, Vol. 53 Issue 61, p8608-8611, 4p
- Publication Year :
- 2017
-
Abstract
- A novel cascade reaction of internal alkynols with 1-(2-aminophenyl)prop-2-ynols has been developed to form a new N,O-containing fused 5,5,6-tricyclic skeleton. Mechanistic studies indicate that this reaction proceeds via alkynol cycloisomerization, intermolecular substitution with 1-(2-aminophenyl)prop-2-ynols, and intermolecular addition with alkynols and consequent cyclizations. In this way, two C–C bonds, one C–O bond and one C–N bond form to give a tricyclic skeleton in a single reaction. [ABSTRACT FROM AUTHOR]
- Subjects :
- YNOLS
CHEMICAL reactions
CYCLOISOMERIZATION
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 53
- Issue :
- 61
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 124318081
- Full Text :
- https://doi.org/10.1039/c7cc04126h