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FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer.
- Source :
- Science Translational Medicine; 8/2/2017, Vol. 9 Issue 401, p1-10, 10p
- Publication Year :
- 2017
-
Abstract
- The article discusses the changes in microRNA expression which can be delivered in the absence of a protective vehicle. It examines the lack of efficient delivery vehicles in microRNA (miRNA)-based therapeutics that could lead to the degradation in circulation and poor transfection efficiency. It also cites the poor transfection efficiency cell surface receptors on tumor cells for the enhancement of miRNA mimic delivery.
- Subjects :
- MICRORNA
GENE expression
THERAPEUTICS
GENE transfection
CELLS
Subjects
Details
- Language :
- English
- ISSN :
- 19466234
- Volume :
- 9
- Issue :
- 401
- Database :
- Complementary Index
- Journal :
- Science Translational Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 124405799
- Full Text :
- https://doi.org/10.1126/scitranslmed.aam9327