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The soluble transcobalamin receptor (sCD320) in relation to Alzheimer's disease and cognitive scores.
- Source :
- Scandinavian Journal of Clinical & Laboratory Investigation; Sep2017, Vol. 77 Issue 5, p332-337, 6p
- Publication Year :
- 2017
-
Abstract
- The soluble transcobalamin receptor (sCD320) is present in cerebrospinal fluid and correlates with the dementia-related biomarkers phospho-tau and total-tau. Here we present data on the relation of sCD320 to Alzheimer’s disease and scores of cognitive tests. Lumbar cerebrospinal fluid samples from 42 pathologically-confirmed cases of Alzheimer’s disease and 25 non-demented controls were analyzed for sCD320 employing an in-house ELISA. The participants’ cognitive functions were tested using the Cambridge Cognition Examination (CAMCOG) and the Mini-Mental State Examination (MMSE). There was no significant difference in the median CSF sCD320 concentration between patients and controls. The median (2.5–97.5 percentiles) sCD320 for all participants (n = 67) was 15 (3–29) pmol/L. We observed a non-linear correlation between sCD320 and cognitive scores. Spearman’s correlation between sCD320 and total CAMCOG scores was 0.627 (n = 16,p = .009) for CAMCOG scores ≤27, and −0.293 (n = 39,p = .071) for CAMCOG scores ≥68. Spearman’s correlation between sCD320 and both the low (≤9) and high (≥16) total MMSE scores was 0.274, −0.363 (n = 18, 44),p = .272, .016, respectively. In conclusion, sCD320 cannot be employed as a biomarker for differentiating Alzheimer dementia patients from controls. Further studies are warranted to explore the non-linear correlations between sCD320 and scores of cognitive function. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 00365513
- Volume :
- 77
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Scandinavian Journal of Clinical & Laboratory Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 124435246
- Full Text :
- https://doi.org/10.1080/00365513.2017.1323345