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The Penicillin for the Emergency Department Outpatient treatment of CELLulitis (PEDOCELL) trial: update to the study protocol and detailed statistical analysis plan (SAP).
- Source :
- Trials; 8/24/2017, Vol. 18, p1-9, 9p
- Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>Cellulitis is a painful, potentially serious, infectious process of the dermal and subdermal tissues and represents a significant disease burden. The statistical analysis plan (SAP) for the Penicillin for the Emergency Department Outpatient treatment of CELLulitis (PEDOCELL) trial is described here. The PEDOCELL trial is a multicentre, randomised, parallel-arm, double-blinded, non-inferiority clinical trial comparing the efficacy of flucloxacillin (monotherapy) with combination flucloxacillin/phenoxymethylpenicillin (dual therapy) for the outpatient treatment of cellulitis in the emergency department (ED) setting. To prevent outcome reporting bias, selective reporting and data-driven results, the a priori-defined, detailed SAP is presented here.<bold>Methods/design: </bold>Patients will be randomised to either orally administered flucloxacillin 500 mg four times daily and placebo or orally administered 500 mg of flucloxacillin four times daily and phenoxymethylpenicillin 500 mg four times daily. The trial consists of a 7-day intervention period and a 2-week follow-up period. Study measurements will be taken at four specific time points: at patient enrolment, day 2-3 after enrolment and commencing treatment (early clinical response (ECR) visit), day 8-10 after enrolment (end-of-treatment (EOT) visit) and day 14-21 after enrolment (test-of-cure (TOC) visit). The primary outcome measure is investigator-determined clinical response measured at the TOC visit. The secondary outcomes are as follows: lesion size at ECR, clinical treatment failure at each follow-up visit, adherence and persistence of trial patients with orally administered antibiotic therapy at EOT, health-related quality of life (HRQoL) and pharmacoeconomic assessments. The plan for the presentation and comparison of baseline characteristics and outcomes is described in this paper.<bold>Discussion: </bold>This trial aims to establish the non-inferiority of orally administered flucloxacillin monotherapy with orally administered flucloxacillin/phenoxymethylpenicillin dual therapy for the ED-directed outpatient treatment of cellulitis. In doing so, this trial will bridge a knowledge gap in this understudied and common condition and will be relevant to clinicians across several different disciplines. The SAP for the PEDOCELL trial was developed a priori in order to minimise analysis bias.<bold>Trial Registration: </bold>EU Clinical Trials Register (EudraCT number: 2016-001528-69). Registered on 5 April 2016. ClinicalTrials.gov, ID: NCT02922686 . Registered on 9 August 2016. [ABSTRACT FROM AUTHOR]
- Subjects :
- CELLULITIS treatment
PENICILLIN
OUTPATIENT medical care
EMERGENCY medical services
HEALTH outcome assessment
THERAPEUTICS
HOSPITAL emergency services
ANTIBIOTICS
CELLULITIS
COMBINATION drug therapy
COMPARATIVE studies
COST effectiveness
DRUGS
DRUG administration
EXPERIMENTAL design
RESEARCH methodology
MEDICAL care costs
MEDICAL cooperation
RESEARCH protocols
ORAL drug administration
PATIENT compliance
QUALITY of life
RESEARCH
STATISTICS
TIME
DATA analysis
EVALUATION research
RANDOMIZED controlled trials
TREATMENT effectiveness
BLIND experiment
QUALITY-adjusted life years
OXACILLIN
STATISTICAL models
DIAGNOSIS
ECONOMICS
Subjects
Details
- Language :
- English
- ISSN :
- 17456215
- Volume :
- 18
- Database :
- Complementary Index
- Journal :
- Trials
- Publication Type :
- Academic Journal
- Accession number :
- 124825980
- Full Text :
- https://doi.org/10.1186/s13063-017-2121-2