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In silico prediction of Leishmania major-specific CD8+ epitopes.
- Source :
- Experimental Dermatology; Sep2017, Vol. 26 Issue 9, p838-840, 3p
- Publication Year :
- 2017
-
Abstract
- Infections with Leishmania (L.) major induce protective IFN-γ-dependent Th1/Tc1 immunity in C57 BL/6 mice as well as in immunocompetent humans. Even though antigen-specific immunity provides lifelong immunity against reinfection, a vaccine against this pathogen does not yet exist. Here, we compared the results obtained from in silico predictions of murine CD8-specific L. major peptides using the algorithm SYFPEITHI with the number and predicted affinity of known proteins/peptides. Our results indicate that the majority of 'immunodominant' epitopes of L. major have not been identified so far; thus, computer-based prediction algorithms may aid the development of an effective vaccine. [ABSTRACT FROM AUTHOR]
- Subjects :
- LEISHMANIA
IMMUNOCOMPETENT cells
EPITOPES
PATHOGENIC microorganisms
IMMUNE response
Subjects
Details
- Language :
- English
- ISSN :
- 09066705
- Volume :
- 26
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Experimental Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 124834572
- Full Text :
- https://doi.org/10.1111/exd.13295