Toxicological implications of the therapeutic use of Acalypha wilkesiana leaves in traditional medicine.

Background: In traditional medicine, Acalypha wilkesiana is frequently used solely or as a composite part of many herbal preparations for therapeutic purposes. This study was therefore conducted to evaluate the effects of oral administration of extracts of Acalypha wilkesiana leaves, on some serum diagnostic enzymes in normal experimental rabbits. Methods: Eighteen adult male experimental rabbits were randomized into three groups (A, B and C), comprising of six animals each. Group A animals were given aqueous extracts of Acalypha wilkesiana leaves, while group B animals were given ethanol extracts of Acalypha wilkesiana leaves. The extracts were administered orally at a dose of 300 mg/kg body weight for a period of twenty-one (21) days. Group C animals were given water, thus they served as control. Data are represented as Mean ± S.E.M ( n = 6). Significance of Difference was tested by ANOVA at P < 0.05. Results: Administration of the aqueous or ethanol extracts, to the experimental animals resulted in a significantly ( P < 0.05) higher alkaline phosphatase (ALP) and lactate dehydrogenase (LDH), non-significantly ( P > 0.05) lower serum total bilirubin, direct bilirubin, Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), gamma glutamyl transferase (GGT) and creatinine kinase (CK), as compared with the control animals. Conclusion: In view of the effects of the plant extracts on ALP and LDH levels, the use of Acalypha wilkesiana leaf in traditional medicine should be with caution. [ABSTRACT FROM AUTHOR]