ARTISAN PCR: rapid identification of full-length immunoglobulin rearrangements without primer binding bias.

The article focuses on a study regarding the use of polymerase chain reaction (PCR) for rapid identification of full-length immunoglobulin rearrangements without primer binding bias. It mentions that B cells recognize specific antigens by their membrane-bound B-cell receptor (BCR). It also mentions that non-templated point mutations are introduced into BCR genes by somatic hypermutation (SHM).