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Pathogenesis, Transmissibility, and Tropism of a Highly Pathogenic Avian Influenza A(H7N7) Virus Associated With Human Conjunctivitis in Italy, 2013.
- Source :
- Journal of Infectious Diseases; 2017 Supplement, Vol. 216, pS508-S511, 4p
- Publication Year :
- 2017
-
Abstract
- H7 subtype influenza viruses represent a persistent public health threat because of their continued detection in poultry and ability to cause human infection. An outbreak of highly pathogenic avian influenza H7N7 virus in Italy during 2013 resulted in 3 cases of human conjunctivitis. We determined the pathogenicity and transmissibility of influenza A/Italy/3/2013 virus in mouse and ferret models and examined the replication kinetics of this virus in several human epithelial cell types. The moderate virulence observed in mammalian models and the capacity for transmission in a direct contact model underscore the need for continued study of H7 subtype viruses. [ABSTRACT FROM AUTHOR]
- Subjects :
- AVIAN influenza
CONJUNCTIVITIS
ANIMAL models in research
EPITHELIAL cells
MICROBIAL virulence
EPIDEMIOLOGY
INFLUENZA diagnosis
AVIAN influenza diagnosis
VIRAL conjunctivitis
ANIMAL experimentation
BIOLOGICAL models
CELL culture
ENDOTHELIUM
MAMMALS
MICE
NASAL mucosa
POULTRY
RESEARCH funding
VIRAL physiology
INFLUENZA A virus
PHYSIOLOGY
DIAGNOSIS
INFECTIOUS disease transmission
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 216
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 125318172
- Full Text :
- https://doi.org/10.1093/infdis/jiw559