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Lack of interaction of lopinavir solid drug nanoparticles with cells of the immune system.
- Source :
- Nanomedicine; Sep2017, Vol. 12 Issue 17, p2043-2054, 12p
- Publication Year :
- 2017
-
Abstract
- Aim: We previously demonstrated that solid drug nanoparticles (SDNs) lopinavir (LPV) dispersed into aqueous media display favorable pharmacokinetics. Methods: The impact of LPV SDNs on the function and phenotype of primary human T cells and macrophages (primary sites of HIV replication) was investigated. Results: LPV significantly increased IL-1β (ninefold higher than untreated cells; p = 0.045) and TNF-α (sixfold higher than untreated cells; p = 0.018) secretion from monocyte-derived macrophages, whereas LPV SDNs did not elicit these responses at comparable drug concentrations. LPV SDNs were demonstrated to be immunologically inert to human T cells and monocyte-derived macrophages. Conclusion: The LPV SDN was demonstrated to exhibit comparable, or favorable behavior compared with an LPV aqueous solution in the employed biocompatibility assessments. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17435889
- Volume :
- 12
- Issue :
- 17
- Database :
- Complementary Index
- Journal :
- Nanomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 125369495
- Full Text :
- https://doi.org/10.2217/nnm-2017-0095