The association of wildfire smoke with respiratory and cardiovascular emergency department visits in Colorado in 2012: a case crossover study.

<bold>Background: </bold>In 2012, Colorado experienced one of its worst wildfire seasons of the past decade. The goal of this study was to investigate the relationship of local PM2.5 levels, modeled using the Weather Research and Forecasting Model with Chemistry, with emergency department visits and acute hospitalizations for respiratory and cardiovascular outcomes during the 2012 Colorado wildfires.<bold>Methods: </bold>Conditional logistic regression was used to assess the relationship between both continuous and categorical PM2.5 and emergency department visits during the wildfire period, from June 5(th) to July 6(th) 2012.<bold>Results: </bold>For respiratory outcomes, we observed positive relationships between lag 0 PM2.5 and asthma/wheeze (1 h max OR 1.01, 95 % CI (1.00, 1.01) per 10 μg/m(3); 24 h mean OR 1.04 95 % CI (1.02, 1.06) per 5 μg/m(3)), and COPD (1 h max OR 1.01 95 % CI (1.00, 1.02) per 10 μg/m(3); 24 h mean OR 1.05 95 % CI (1.02, 1.08) per 5 μg/m(3)). These associations were also positive for 2-day and 3-day moving average lag periods. When PM2.5 was modeled as a categorical variable, bronchitis also showed elevated effect estimates over the referent groups for lag 0 24 h average concentration. Cardiovascular results were consistent with no association.<bold>Conclusions: </bold>We observed positive associations between PM2.5 from wildfire and respiratory diseases, supporting evidence from previous research that wildfire PM2.5 is an important source for adverse respiratory health outcomes. [ABSTRACT FROM AUTHOR]