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Evaluation of the Accuracy of T-SPOT.TB for the Diagnosis of Ocular Tuberculosis in a BCG-vaccinated, Non-endemic Population.
- Source :
- Ocular Immunology & Inflammation; August 2017, Vol. 25 Issue 4, p455-459, 5p
- Publication Year :
- 2017
-
Abstract
- <bold>Purpose: </bold>To determine the performance of T-SPOT.TB, an interferon gamma release assay test, in patients with ocular tuberculosis (TB) in a BCG-vaccinated, non-endemic population.<bold>Methods: </bold>We employed a nested case-control design. In total, 45 subjects were enrolled (23 patients with ocular tuberculosis and 22 patients with other causes of uveitis). A blood sample was collected from each subject, and T-SPOT.TB was executed. Laboratory professionals were blinded to the disease status of each subject.<bold>Results: </bold>Five patients were excluded because of indeterminate results. The calculated sensitivity and specificity were 0.80 and 0.85, respectively. The positive likelihood ratio was 5.33 and the negative likelihood ratio was 0.23. The overall accuracy of the test was 0.83.<bold>Conclusions: </bold>T-SPOT.TB adequately diagnosed ocular TB. This technique is particularly useful in populations where BCG vaccinations are still mandatory. [ABSTRACT FROM AUTHOR]
- Subjects :
- EYE diseases
TUBERCULOSIS diagnosis
INTERFERON gamma release tests
BCG vaccines
EYE inflammation
HISTOPATHOLOGY
ACCURACY
DIAGNOSIS
TUBERCULOSIS prevention
BACTERIAL antigens
COMPARATIVE studies
DIAGNOSTIC errors
IMMUNIZATION
INTERFERONS
RESEARCH methodology
MEDICAL cooperation
MYCOBACTERIUM tuberculosis
PROBABILITY theory
RESEARCH
RESEARCH evaluation
T cells
EVALUATION research
PREDICTIVE tests
CASE-control method
Subjects
Details
- Language :
- English
- ISSN :
- 09273948
- Volume :
- 25
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Ocular Immunology & Inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 125479756
- Full Text :
- https://doi.org/10.3109/09273948.2015.1135965