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Immunomodulatory effects of <em>Bacteroides</em> products on <em>in vitro</em> human lymphocyte functions.
- Source :
- Oral Microbiology & Immunology; Mar1989, Vol. 4 Issue 1, p24-29, 6p
- Publication Year :
- 1989
-
Abstract
- <em>Bacteroides</em> spp. have been implicated in the pathogenesis of several diseases, including periodontal diseases. In this study sonic extracts of 6 <em>Bacteroides</em> spp. were examined for their abilities to alter human lymphocyte function. We found that soluble extracts from <em>Bacteroides intermedius, Bacteroides endodontalis, Bacteroides asaccharolyticus, Bacteroides melaninogenicus</em>, and to a lesser degree <em>Bacteroides loescheii</em>, caused dose-dependent inhibition of human lymphocyte responsiveness to both mitogens and antigens. Suppression involved altered DNA, RNA and protein synthesis as well as immunoglobulin production. In contrast, <em>Bacteroides gingivalis</em> did not suppress these responses; instead, it stimulated lymphocyte proliferation and enhanced immunoglobulin production. It has been proposed that impaired host defense may play a pivotal role in the pathogenesis of many infections. The data presented in this paper suggest that microbial mediated immunosuppression may conceivably alter the nature and consequences of host-parasite interactions in periodontal disease. [ABSTRACT FROM AUTHOR]
- Subjects :
- LYMPHOCYTES
IMMUNOREGULATION
BACTEROIDES
IMMUNOGLOBULINS
ANTIGENS
PROTEIN synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 09020055
- Volume :
- 4
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Oral Microbiology & Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 12548495
- Full Text :
- https://doi.org/10.1111/j.1399-302X.1989.tb00402.x