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Endoreduplication in conjunction with tumor progression in an aneuploid laryngeal squamous cell carcinoma.
- Source :
- Virchows Archiv: European Journal of Pathology; Jul2003, Vol. 443 Issue 1, p98-103, 6p
- Publication Year :
- 2003
-
Abstract
- We report the case of a 58-year-old man who presented with a squamous cell carcinoma pT1a G2 of the left vocal cord. Six months after histologically verified complete resection, the patient experienced an endolaryngeal and extralaryngeal local recurrence pT4 pN2b G2. We applied DNA flow cytometry (FCM) and comparative genomic hybridization (CGH) on both primary and recurrent tumor. The primary tumor and the endolaryngeal compartment of the relapse was an aneuploid cell clone with a FCM DNA index of 1.42 and 1.44, respectively. The extralaryngeal compartment showed a shift featuring a DNA index of 2.78. In the primary tumor and in both compartments of the recurrence there was an identical pattern of complex chromosomal imbalances as detected in CGH (CGH karyotype: rev ish enh [8q24.2-q24.3, 10q26.1-q26.3, 11q24-q25, 12q24.2-q23.33,X], dim [4q, 13q14.3-q31], amp[1p36.1-p36.2]). Hence, the recurrence was not associated with further gains and losses of chromosomal material. However, in the anterior part of the recurrence, the aneuploid tumor cell genome had completely doubled, obviously due to endoreduplication. Immunohistochemical analysis of several cell-cycle regulators revealed altered expression of checkpoint proteins, pointing to a complex disturbance in cell-cycle regulation. [ABSTRACT FROM AUTHOR]
- Subjects :
- CANCER treatment
DNA analysis
ANEUPLOIDY
CANCER relapse
COMBINED modality therapy
COMPARATIVE studies
FLOW cytometry
LARYNGECTOMY
LARYNGEAL tumors
RESEARCH methodology
MEDICAL cooperation
PROGNOSIS
RADIOTHERAPY
RESEARCH
SQUAMOUS cell carcinoma
EVALUATION research
TREATMENT effectiveness
DISEASE progression
TUMOR treatment
Subjects
Details
- Language :
- English
- ISSN :
- 09456317
- Volume :
- 443
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Virchows Archiv: European Journal of Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 125513395