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Effects of realgar (As4S4) on degradation of PML-RARA harboring acquired arsenic-resistance mutations.
- Source :
- Annals of Hematology; Nov2017, Vol. 96 Issue 11, p1945-1948, 4p
- Publication Year :
- 2017
-
Abstract
- The article discusses findings of a study on effects of realgar (As4S4) on degradation of promyelocytic leukemia gene (PML)-RARA fusion protein. It states role of PML-RARA as a therapy target of acute promyelocytic leukemia (APL), and mentions that arsenic trioxide cures APL by binding to the PML moiety and triggering the degradation of PML-RARA oncoprotein. It notes that most of the identified arsenic-resistance mutations were found to be located in the PML B2 domain of PML-RARA.
- Subjects :
- ARSENIC sulfide
LEUKEMIA
CANCER genetics
GENETIC mutation
LEUKEMIA genetics
Subjects
Details
- Language :
- English
- ISSN :
- 09395555
- Volume :
- 96
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Annals of Hematology
- Publication Type :
- Academic Journal
- Accession number :
- 125727840
- Full Text :
- https://doi.org/10.1007/s00277-017-3093-8