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Negative legacy of obesity.
- Source :
- PLoS ONE; 10/26/2017, Vol. 12 Issue 10, p1-12, 12p
- Publication Year :
- 2017
-
Abstract
- Obesity promotes excessive inflammation, which is associated with senescence-like changes in visceral adipose tissue (VAT) and the development of type 2 diabetes (T2DM) and cardiovascular diseases. We have reported that a unique population of CD44<superscript>hi</superscript> CD62L<superscript>lo</superscript> CD4<superscript>+</superscript> T cells that constitutively express PD-1 and CD153 exhibit cellular senescence and cause VAT inflammation by producing large amounts of osteopontin. Weight loss improves glycemic control and reduces cardiovascular disease risk factors, but its long-term effects on cardiovascular events and longevity in obese individuals with T2DM are somewhat disappointing and not well understood. High-fat diet (HFD)-fed obese mice were subjected to weight reduction through a switch to a control diet. They lost body weight and visceral fat mass, reaching the same levels as lean mice fed a control diet. However, the VAT of weight reduction mice exhibited denser infiltration of macrophages, which formed more crown-like structures compared to the VAT of obese mice kept on the HFD. Mechanistically, CD153<superscript>+</superscript> PD-1<superscript>+</superscript> CD4<superscript>+</superscript> T cells are long-lived and not easily eliminated, even after weight reduction. Their continued presence maintains a self-sustaining chronic inflammatory loop via production of large amounts of osteopontin. Thus, we concluded that T-cell senescence is essentially a negative legacy effect of obesity. [ABSTRACT FROM AUTHOR]
- Subjects :
- OBESITY
ADIPOSE tissues
TYPE 2 diabetes
OSTEOPONTIN
HIGH-fat diet
T cells
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- 125889913
- Full Text :
- https://doi.org/10.1371/journal.pone.0186303