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Aervfuranoside: A New Chlorinated Dibenzofuran Glycoside and other Metabolites from the Flowers of Aerva javanica.
- Source :
- Journal of the Chemical Society of Pakistan; Aug2017, Vol. 39 Issue 4, p572-577, 6p
- Publication Year :
- 2017
-
Abstract
- Aervfuranoside (1), a new chlorinated dibenzofuran glycoside together with ten (2-11) known compounds were isolated from ethyl acetate soluble fraction of methanolic extract of the flowers of Aerva javanica. The structures of isolates were elucidated by the combination of 1D (¹H and <superscript>13</superscript>C-NMR), 2D (HMQC, HMBC and COSY) NMR spectroscopy and mass spectrometry (FABMS, HRFABMS) or in comparison with the literature data in case of known metabolites. Among these isolates, only compounds 1-3 were evaluated for DPPH free radical scavenging potential and enzyme inhibitory activity against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), lipoxygenase (LOX) and metallo-ß-lactamase (IMP-1). The test compound 2 exhibited moderate inhibition of the enzyme lipoxygenase with the IC50 value of 53.5 µM. [ABSTRACT FROM AUTHOR]
- Subjects :
- DIBENZOFURANS
GLYCOSIDES
METABOLITES
AERVA
ETHYL acetate
Subjects
Details
- Language :
- English
- ISSN :
- 02535106
- Volume :
- 39
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of the Chemical Society of Pakistan
- Publication Type :
- Academic Journal
- Accession number :
- 126050021