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Elevated Levels of Interferon- Are Associated with High Levels of Epstein-Barr Virus Reactivation in Patients with the Intestinal Type of Gastric Cancer.
- Source :
- Journal of Immunology Research; 11/14/2017, p1-10, 10p
- Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>The inflammatory response directed against Helicobacter pylori (HP) is believed to be one of the main triggers of the appearance of gastric lesions and their progression to gastric cancer (GC). Epstein-Barr virus (EBV) has been found responsible for about 10% of all GCs, but the inflammatory response has not been studied in GC patients with evidence of high levels of EBV reactivation.<bold>Objective: </bold>To determine the relationship between inflammation and antibodies against EBV reactivation antigens, HP, and the bacterium virulence factor CagA in patients with GC.<bold>Methods: </bold>127 GC patients, 46 gastritis patients, and 197 healthy subjects were studied. IL-1β, IL-6, IL-8, IL-10, TNF-α, TGF-β, MCP-1, and IFN-γ levels were measured in serum or plasma and compared against the antibody titers of VCA-IgG, HP, and the HP virulence factor CagA. Statistical associations were estimated.<bold>Results: </bold>Significant ORs and positive trends were found between VCA-IgG and IFN-γ, specifically for patients with GC of intestinal type (OR: 6.4, 95% C.I. 1.2-35.4) (p < 0.044).<bold>Conclusions: </bold>We confirmed a positive association between a marker of EBV reactivation and intestinal gastric cancer and present evidence of a correlation with elevated serum levels of IFN-γ, but not with the other cytokines. [ABSTRACT FROM AUTHOR]
- Subjects :
- HELICOBACTER pylori
EPSTEIN-Barr virus
INFLAMMATION
CYTOKINES
GASTRIC diseases
Subjects
Details
- Language :
- English
- ISSN :
- 23148861
- Database :
- Complementary Index
- Journal :
- Journal of Immunology Research
- Publication Type :
- Academic Journal
- Accession number :
- 126219749
- Full Text :
- https://doi.org/10.1155/2017/7069242