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Elevated Levels of Interferon- Are Associated with High Levels of Epstein-Barr Virus Reactivation in Patients with the Intestinal Type of Gastric Cancer.

Authors :
Cárdenas-Mondragón, María G.
Torres, Javier
Sánchez-Zauco, Norma
Gómez-Delgado, Alejandro
Camorlinga-Ponce, Margarita
Maldonado-Bernal, Carmen
Fuentes-Pananá, Ezequiel M.
Cárdenas-Mondragón, María G
Sánchez-Zauco, Norma
Gómez-Delgado, Alejandro
Fuentes-Pananá, Ezequiel M
Source :
Journal of Immunology Research; 11/14/2017, p1-10, 10p
Publication Year :
2017

Abstract

<bold>Background: </bold>The inflammatory response directed against Helicobacter pylori (HP) is believed to be one of the main triggers of the appearance of gastric lesions and their progression to gastric cancer (GC). Epstein-Barr virus (EBV) has been found responsible for about 10% of all GCs, but the inflammatory response has not been studied in GC patients with evidence of high levels of EBV reactivation.<bold>Objective: </bold>To determine the relationship between inflammation and antibodies against EBV reactivation antigens, HP, and the bacterium virulence factor CagA in patients with GC.<bold>Methods: </bold>127 GC patients, 46 gastritis patients, and 197 healthy subjects were studied. IL-1β, IL-6, IL-8, IL-10, TNF-α, TGF-β, MCP-1, and IFN-γ levels were measured in serum or plasma and compared against the antibody titers of VCA-IgG, HP, and the HP virulence factor CagA. Statistical associations were estimated.<bold>Results: </bold>Significant ORs and positive trends were found between VCA-IgG and IFN-γ, specifically for patients with GC of intestinal type (OR: 6.4, 95% C.I. 1.2-35.4) (p < 0.044).<bold>Conclusions: </bold>We confirmed a positive association between a marker of EBV reactivation and intestinal gastric cancer and present evidence of a correlation with elevated serum levels of IFN-γ, but not with the other cytokines. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
23148861
Database :
Complementary Index
Journal :
Journal of Immunology Research
Publication Type :
Academic Journal
Accession number :
126219749
Full Text :
https://doi.org/10.1155/2017/7069242