High-dose pulsed corticosteroid therapy combined with methotrexate for severe alopecia areata of childhood.

The article focuses on a study regarding the ineffective use of high-dose pulsed corticosteroid therapy (HDPCT) in the long term combined with methotrexate for severe alopecia areata of childhood. It mentions alopecia totalis (AAT) and universalis (AAU) who failed topical therapy underwent treatment and intravenous methylprednisolone. It also mentions methotrexate may exert its anti-inflammatory effect by increasing adenosine levels which reduce cytokine synthesis.