Back to Search
Start Over
Ischemic Stroke Patients Demonstrate Increased Carotid Plaque Microvasculature Compared to (Ocular) Transient Ischemic Attack Patients.
- Source :
- Cerebrovascular Diseases; Dec2017, Vol. 44 Issue 5/6, p297-303, 7p, 1 Black and White Photograph, 3 Charts, 1 Graph
- Publication Year :
- 2017
-
Abstract
- Background: Patients with a recent ischemic stroke have a higher risk of recurrent stroke compared to (ocular) transient ischemic attack (TIA) patients. Plaque microvasculature is considered as a feature of plaque vulnerability and can be quantified with carotid dynamic contrast-enhanced MRI (DCE-MRI). The purpose of this cross-sectional study was to explore the association between plaque microvasculature and the type of recent cerebrovascular events in symptomatic patients with mild-to-moderate carotid stenosis. Methods: A total of 87 symptomatic patients with a recent stroke (n = 35) or (ocular) TIA (n = 52) underwent carotid DCE-MRI examination. Plaque microvasculature was studied in the vessel wall and adventitia using DCEMRI and the pharmacokinetic modeling parameter K<superscript>trans</superscript>. Statistical analysis was performed with logistic regression, correcting for associated clinical risk factors. Results: The 75th percentile adventitial (OR 1.97, 95% CI 1.18-3.29) K<superscript>trans</superscript> was significantly associated with a recent ischemic stroke compared to (ocular) TIA in multivariate analysis, while clinical risk factors were not significantly associated with the type of event. Conclusions: This study indicates a positive association of leaky plaque microvasculature with a recent ischemic stroke compared to (ocular) TIA. Prospective longitudinal studies are needed to investigate whether K<superscript>trans</superscript> or other plaque characteristics may serve as an imaging marker for predicting (the type of) future cerebrovascular events. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10159770
- Volume :
- 44
- Issue :
- 5/6
- Database :
- Complementary Index
- Journal :
- Cerebrovascular Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 126691414
- Full Text :
- https://doi.org/10.1159/000481146