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Are there any new insights for G-CSF and/or AMD3100 in chemotherapy of haematological malignants?

Authors :
Shen, Zhao-Hua
Zeng, Dong-Feng
Ma, Ying-ying
Zhang, Xi
Zhang, Cheng
Kong, Pei-Yan
Source :
Medical Oncology; Dec2015, Vol. 32 Issue 12, p1-6, 6p
Publication Year :
2015

Abstract

AML is a common life-threatening blood system malignancy. The treatment of AML continues to face greater challenges. An abnormal haematopoietic niche with high adhesion and proliferation might be the root cause of resistance and relapse. Most leukaemia cells are stored in the endosteal niche and recess in the G phase, and they are not sensitive to varieties of radiotherapies and chemotherapies. G-CSF and AMD3100 are increasingly used in priming chemotherapy. G-CSF can promote leukaemia cells to the cell cycle, which improves the complete remission rate of leukaemia patients. AMD3100, the novel CXCR4 antagonist, could also potentially promote leukaemia cells to cell cycle and improve the susceptibility of leukaemia cells to chemotherapeutic agents. The combination of them enhances anti-leukaemia effect. So in this review, we explore the function of G-CSF and/or AMD3100 in the priming chemotherapy of haematological malignants. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13570560
Volume :
32
Issue :
12
Database :
Complementary Index
Journal :
Medical Oncology
Publication Type :
Academic Journal
Accession number :
126734983
Full Text :
https://doi.org/10.1007/s12032-015-0705-9