Back to Search
Start Over
A single dose of dezocine suppresses emergence agitation in preschool children anesthetized with sevoflurane-remifentanil.
- Source :
- BMC Anesthesiology; 11/22/2017, Vol. 17, p1-6, 6p
- Publication Year :
- 2017
-
Abstract
- Background: Emergence agitation (EA) is a common phenomenon in preschool children during emergence from general anesthesia. This study evaluated the safety and efficacy of dezocine for emergence agitation in preschool children anesthetized with sevoflurane-remifentanil. Methods: A total of 100 preschool children, scheduled for elective laparoscopic repair of an inguinal hernia by high ligation of the hernia sac under sevoflurane-remifentanil anesthesia were randomized into two groups: Group C(n = 50) received Ringer's lactate 10 mL and Group D received Ringer's lactate 10 mL containing dezocine 0.1 mg/kg, postoperatively. Results: Incidence of EA, defined as a score ≥ 3onAono's four point scale or Pediatric Anesthesia Emergence Delirium (PAED) score ≥ 10 in the PACU (10% vs. 76%) and the percentage of patients with severe EA (PAED score ≥ 13) (12% vs. 76%) were significantly lower in Group D compared to Group C (P < 0.05). Mean Children and Infants Postoperative Pain Scale (CHIPPS) score was significantly lower in Group D compared to Group C (1.2 ± 0.5 vs. 5.2 ± 0.6; P < 0.05). Patients need for fentanyl (18% vs. 4%) or propofol rescue (20% vs. 0) was significantly greater in Group C compared to Group D. No significant differences in other relative aspects after surgery between groups. Conclusion: Administration of dezocine 0.1 mg/kg decreased the incidence and severity of EA in preschool children that had undergone laparoscopic repair of an inguinal hernia by high ligation of the hernia sac under sevoflurane-remifentanil anesthesia. Trial registration: A single dose of dezocine suppresses emergence agitation in preschool children anesthetized with sevoflurane-remifentanil effectively: A double-blind, prospective, randomized, controlled study, Chinese Clinical Trial Registry (ID: ChiCTR-IOR-16010033), retrospectively registered on November 21, 2016. [ABSTRACT FROM AUTHOR]
- Subjects :
- THERAPEUTIC use of narcotics
INGUINAL hernia
ANALGESICS
BLOOD plasma substitutes
DELIRIUM
FENTANYL
LAPAROSCOPIC surgery
LOCAL anesthetics
LONGITUDINAL method
NARCOTICS
POSTOPERATIVE pain
RANDOMIZED controlled trials
DISEASE incidence
BLIND experiment
SEVERITY of illness index
PROPOFOL
SEVOFLURANE
CHILDREN
SURGERY
Subjects
Details
- Language :
- English
- ISSN :
- 14712253
- Volume :
- 17
- Database :
- Complementary Index
- Journal :
- BMC Anesthesiology
- Publication Type :
- Academic Journal
- Accession number :
- 126955842
- Full Text :
- https://doi.org/10.1186/s12871-017-0446-8