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Prevalence of nonalcoholic fatty liver disease in normal-weight and overweight preadolescent children in Haryana, India.
- Source :
- Indian Pediatrics; Dec2017, Vol. 54 Issue 12, p1012-1016, 5p
- Publication Year :
- 2017
-
Abstract
- Objective: To document the prevalence of non-alcoholic fatty liver disease (NAFLD) and metabolic parameters among normalweight and overweight schoolchildren. Design: Cross-sectional study. Setting: Thirteen private schools in urban Faridabad, Haryana. Participants: 961 school children aged 5-10 years. Methods: Ultrasound testing was done, and 215 with fatty liver on ultrasound underwent further clinical, biochemical and virological testing. Outcome measures: Prevalence of fatty liver on ultrasound, and NAFLD and its association with biochemical abnormalities and demographic risk factors. Results: On ultrasound, 215 (22.4%) children had fatty liver; 18.9% in normal-weight and 45.6% in overweight category. Presence and severity of fatty liver disease increased with body mass index (BMI) and age. Among the children with NAFLD, elevated SGOT and SGPT was observed in 21.5% and 10.4% children, respectively. Liver enzyme derangement was significantly higher in overweight children (27% vs 19.4% in normal-weight) and severity of fatty liver (28% vs 20% in mild fatty liver cases). Eleven (8.1%) children with NAFLD had metabolic syndrome. Higher BMI (OR 35.9), severe fatty liver disease (OR 1.7) and female sex (OR 1.9) had strong association with metabolic syndrome. Conclusions: 22.4% of normal-weight and overweight children aged 5-10 years had fatty liver. A high proportion (18.9%) of normal-weight children with fatty liver on ultrasound indicates the silent burden in the population. [ABSTRACT FROM AUTHOR]
- Subjects :
- FATTY liver
DISEASE prevalence
PEDIATRIC gastroenterology
PUBLIC health
BIOCHEMISTRY
Subjects
Details
- Language :
- English
- ISSN :
- 00196061
- Volume :
- 54
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Indian Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 127087495
- Full Text :
- https://doi.org/10.1007/s13312-017-1202-3