Content-based image retrieval for Lung Nodule Classification Using Texture Features and Learned Distance Metric.

Similarity measurement of lung nodules is a critical component in content-based image retrieval (CBIR), which can be useful in differentiating between benign and malignant lung nodules on computer tomography (CT). This paper proposes a new two-step CBIR scheme (TSCBIR) for computer-aided diagnosis of lung nodules. Two similarity metrics, semantic relevance and visual similarity, are introduced to measure the similarity of different nodules. The first step is to search for K most similar reference ROIs for each queried ROI with the semantic relevance metric. The second step is to weight each retrieved ROI based on its visual similarity to the queried ROI. The probability is computed to predict the likelihood of the queried ROI depicting a malignant lesion. In order to verify the feasibility of the proposed algorithm, a lung nodule dataset including 366 nodule regions of interest (ROIs) is assembled from LIDC-IDRI lung images on CT scans. Three groups of texture features are implemented to represent a nodule ROI. Our experimental results on the assembled lung nodule dataset show good performance improvement over existing popular classifiers. [ABSTRACT FROM AUTHOR]