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Unesterified plant sterols and stanols do not affect LDL electrophoretic characteristics in hypercholesterolemic subjects.
- Source :
- Journal of Nutrition; Mar2004, Vol. 134 Issue 3, p592-595, 4p, 2 Charts
- Publication Year :
- 2004
-
Abstract
- The extent to which sterols and stanols modulate LDL particle size is unknown. We examined the effects of supplementation with unesterified plant sterols and stanols on several LDL electrophoretic characteristics. Healthy hypercholesterolemic subjects (n = 14) consumed each of four experimental diets contained plant sterols (S), plant stanols (SN), a 50:50 mixture of sterols and stanols (SSN), or cornstarch (control) in a randomized crossover design. The butter component of the diet was blended with unesterified sterols and stanols at a dose of 1.8 g/d. The LDL particles were characterized by polyacrylamide gradient gel electrophoresis of whole plasma. LDL cholesterol (LDL-C) concentrations decreased by 8.8, 13.6, and 13.1% in the S, SN, and SSN groups, respectively (P < 0.01) with a significant increase of 4.3% in the control group. None of the treatments with sterols and stanols induced significant changes in LDL peak particle diameter or in the cholesterol levels of the small LDL subfraction (<25.5 nm). The reduction in plasma LDL-C levels with SN consumption was due mainly to a decrease (P < 0.05) in the concentration of cholesterol in the large subfraction (>26.0 nm). The significant reduction in plasma LDL-C concentrations by sterol and stanol consumption in subjects was not paralleled by any beneficial changes in LDL electrophoretic characteristics. [ABSTRACT FROM AUTHOR]
- Subjects :
- STEROLS
LOW density lipoproteins
PARTICLE size determination
ELECTROPHORETIC deposition
HYPERCHOLESTEREMIA
CLINICAL trials
COMPARATIVE studies
CROSSOVER trials
HERBAL medicine
HIGH density lipoproteins
HYPERLIPIDEMIA
LIPIDS
RESEARCH methodology
MEDICAL cooperation
RESEARCH
TRIGLYCERIDES
EVALUATION research
RANDOMIZED controlled trials
BLIND experiment
PHYTOSTEROLS
PREVENTION
Subjects
Details
- Language :
- English
- ISSN :
- 00223166
- Volume :
- 134
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 12732765
- Full Text :
- https://doi.org/10.1093/jn/134.3.592