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Effect of Atractylodes macrocephala rhizoma on isoproterenol-induced ventricular remodeling in rats.

Authors :
Cui, Xiao-Hua
Wang, Hui-Lin
Wu, Rong
Yao, Ping-An
Wei, Ke-Zhao
Gao, Jian-Ping
Source :
Molecular Medicine Reports; Feb2018, Vol. 17 Issue 2, p2607-2613, 7p
Publication Year :
2018

Abstract

Myocardial infarction (MI) is the primary cause of ventricular remodeling (VR). The aim of the present study was to determine the effect of Atractylodis macrocephalae rhizoma (AMR) on VR induced by isoproterenol (ISO) in rats. Male Sprague Dawley rats were randomly divided into the normal control, ISO-induced and AMR groups. Rats in the ISO-induced and AMR groups were subcutaneously injected with 85 mg/kg/day ISO for two consecutive days. Compared with the ISO-induced group, AMR normalized the levels of hemodynamic parameters, markedly attenuated myocardial pathological damage, decreased the level of N-terminal prohormone of brain natriuretic peptide, and inhibited cardiac hypertrophy and myocardial fibrosis. In addition, AMR inhibited oxidative stress and activation of the rennin-angiotensin-aldosterone system (RAAS) when compared with the ISO-induced group. The results of the present study suggest that AMR may reverse VR via its antioxidative effect and inhibition of RAAS activation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
17912997
Volume :
17
Issue :
2
Database :
Complementary Index
Journal :
Molecular Medicine Reports
Publication Type :
Academic Journal
Accession number :
127635186
Full Text :
https://doi.org/10.3892/mmr.2017.8121