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Incidence Rates and Risk Factors for Vision Loss among AIDS-Related Cytomegalovirus Retinitis Patients in Southern Thailand.

Authors :
Sittivarakul, Wantanee
Seepongphun, Usanee
Source :
Ocular Immunology & Inflammation; 2018, Vol. 26 Issue 1, p82-89, 8p
Publication Year :
2018

Abstract

<bold>Purpose: </bold>To describe the incidence of and risk factors for visual acuity (VA) loss in patients with AIDS and cytomegalovirus (CMV) retinitis.<bold>Methods: </bold>A total of 132 patients were included. The main outcome measurements were the incidences of VA loss to ≤20/50 and ≤20/200.<bold>Results: </bold>The incidences of VA loss to ≤20/50 and ≤20/200 were 0.22/eye-year (EY) and 0.12/EY, respectively. Risk factors for the incidence of VA loss to ≤20/50 were low nadir CD4+ T-cell count (adjusted hazard ratio [aHR], 3.1), large area of retinitis (aHR, 3.7), and no immune recovery (IR) (aHR, 13.9). Risk factors for the incidence of VA loss to ≤20/200 were not receiving highly active antiretroviral therapy (HAART) (aHR, 4.4) and large retinitis area (aHR, 2.1).<bold>Conclusions: </bold>The incidence of VA loss in eyes affected by CMV retinitis was high. The use of HAART, particularly with subsequent immune recovery, substantially reduced the incidence of VA loss. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09273948
Volume :
26
Issue :
1
Database :
Complementary Index
Journal :
Ocular Immunology & Inflammation
Publication Type :
Academic Journal
Accession number :
127643695
Full Text :
https://doi.org/10.1080/09273948.2017.1283044