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Total Synthesis of (±)‐Phomoidride D.
- Source :
- Angewandte Chemie International Edition; 2/12/2018, Vol. 57 Issue 7, p1991-1994, 4p
- Publication Year :
- 2018
-
Abstract
- Abstract: Described herein is a synthetic strategy for the total synthesis of (±)‐phomoidride D. This highly efficient and stereoselective approach provides rapid assembly of the carbocyclic core by way of a tandem phenolic oxidation/intramolecular Diels–Alder cycloaddition. A subsequent SmI<subscript>2</subscript>‐mediated cyclization cascade delivers an isotwistane intermediate poised for a Wharton fragmentation that unveils the requisite bicyclo[4.3.1]decene skeleton and sets the stage for synthesis completion. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 57
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 127846903
- Full Text :
- https://doi.org/10.1002/anie.201712369