Rat IgE Production I. EFFECT OF DOSE OF ANTIGEN ON PRIMARY AND SECONDARY REAGINIC ANTIBODY RESPONSES.

The experiments described here form part of a series carried out to determine the conditions of antigen presentation which dispose to the production of IgE antibody in the rat. We have found that Hooded Lister rats in comparison with rats of some other strains have an exceptional ability to produce reaginic antibodies responses can be consistently induced with very small doses of antigen and are boosted to high levels with a second dose of antigen. The effect of the dose of antigen on these responses is as follows. [ABSTRACT FROM AUTHOR]