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Concurrent Redistribution of Antigen Receptors and Surface Immunoglobulin on Antigen-Binding Cells.
- Source :
- Immunology; Mar74, Vol. 26 Issue 3, p539-548, 10p
- Publication Year :
- 1974
-
Abstract
- Surface immunoglobulin can be demonstrated on almost all sheep erythrocyte rosette-forming cells in CBA and AKR mice, either by inhibition of antigen binding by anti-immunoglobulin or by immunofluorescence. When surface immunoglobulin on a rosette-forming cell is `capped' by anti-immunoglobulin, the bound red cells migrate with the immunoglobulin, demonstrating that the receptor-combining site and immunoglobulin antigenic determinants share the same mobile unit in the membrane. These observations strongly support the concept that the antigen receptor is surface immunoglobulin (at least for B cells), and illustrate the usefulness of the `capping' technique for studying the associations between membrane elements. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTIGENS
IMMUNOGLOBULINS
IMMUNOFLUORESCENCE
B cells
ERYTHROCYTES
EPITOPES
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 26
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 12826587