Back to Search
Start Over
Influence of genetic polymorphisms of IL23R, STAT3, IL12B, and STAT4 on the risk of aplastic anemia and the effect of immunosuppressive therapy.
- Source :
- Annals of Hematology; Apr2018, Vol. 97 Issue 4, p685-695, 11p
- Publication Year :
- 2018
-
Abstract
- Studies have suggested that IL-23/STAT3 and IL-12/STAT4 signaling pathways associate with aplastic anemia (AA) occurrence. Polymorphisms in pathway-related genes may contribute to AA risk. In the current study, we investigated the association between polymorphisms in genes of IL23R, STAT3, IL12B, and STAT4 and occurrence, severity, and immunosuppressive outcome of AA in the Han population in southwest China. In the current 164 AA cases and 211 controls study, we found T allele and TT genotype of rs7574865 were more frequent in the cases than that in the controls. In the additive model, individual carrying rs7574865 T allele demonstrated a 37% (OR (95% CI) = 1.37 (1.02-1.85), Pper = 0.036) increased AA risk. In the recessive model, carrier with rs7574865 TT genotype showed a 2.08-fold increased AA risk (OR (95% CI) = 2.08 (1.14-3.70), Pper = 0.017). Additionally, we showed that G allele and GG genotype of rs11209032 were more frequent in the 88 non-severe AA cases than that in the 76 severe AA ones. Our study also found G allele and GG genotype of rs11209032, and GG-genotype of rs744166 associated with the immunosuppressive therapy outcome in AA patients. Current study results support that functional STAT4 (rs7574865), IL23R (rs11209032), and STAT3 (rs744166) variants may associate with occurrence, severity, and immunosuppressive outcome of AA in the Han population in southwest China. [ABSTRACT FROM AUTHOR]
- Subjects :
- APLASTIC anemia treatment
APLASTIC anemia
ASIANS
CARRIER proteins
CELL receptors
COMPARATIVE studies
DISEASE susceptibility
GENETIC polymorphisms
GENETIC techniques
IMMUNOSUPPRESSION
LONGITUDINAL method
RESEARCH methodology
MEDICAL cooperation
META-analysis
RESEARCH
EVALUATION research
TREATMENT effectiveness
RETROSPECTIVE studies
SEVERITY of illness index
CASE-control method
Subjects
Details
- Language :
- English
- ISSN :
- 09395555
- Volume :
- 97
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Annals of Hematology
- Publication Type :
- Academic Journal
- Accession number :
- 128272688
- Full Text :
- https://doi.org/10.1007/s00277-018-3227-7