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Evaluating antidisease immunity to malaria and implications for vaccine design.
- Source :
- Immunology; Apr2018, Vol. 153 Issue 4, p423-434, 12p
- Publication Year :
- 2018
-
Abstract
- Summary: Immunity to malaria could be categorized broadly as antiparasite or antidisease immunity. While most vaccine research efforts have focused on antiparasite immunity, the evidence from endemic populations suggest that antidisease immunity is an important component of natural immunity to malaria. The processes that mediate antidisease immunity have, however, attracted little to no attention, and most interests have been directed towards the antibody responses. This review evaluates the evidence for antidisease immunity in endemic areas and discusses the possible mechanisms responsible for it. Given the key role that inflammation plays in the pathogenesis of malaria, regulation of the inflammatory response appears to be a major mechanism for antidisease immunity in naturally exposed individuals. [ABSTRACT FROM AUTHOR]
- Subjects :
- MALARIA
DRUG design
IMMUNITY
INFLAMMATION
EVIDENCE-based medicine
VACCINATION
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 153
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 128331311
- Full Text :
- https://doi.org/10.1111/imm.12877