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Diverse Streptococcus pneumoniae Strains Drive a Mucosal- Associated Invariant T-Cell Response Through Major Histocompatibility Complex class I–Related Molecule– Dependent and Cytokine-Driven Pathways.

Authors :
Ayako Kurioka
Wilgenburg, Bonnie van
Javan, Reza Rezaei
Hoyle, Ryan
van Tonder, Andries J.
Harrold, Caroline L.
Tianqi Leng
Howson, Lauren J.
Shepherd, Dawn
Cerundolo, Vincenzo
Brueggemann, Angela B.
Klenerman, Paul
Source :
Journal of Infectious Diseases; 3/15/2018, Vol. 217 Issue 6, p988-999, 12p
Publication Year :
2018

Abstract

Mucosal-associated invariant T (MAIT) cells represent an innate T-cell population that can recognize ligands generated by the microbial riboflavin synthesis pathway, presented via the major histocompatibility complex class I–related molecule (MR1). Streptococcus pneumoniae is a major human pathogen that is also associated with commensal carriage; thus, host control at the mucosal interface is critical. The recognition of pneumococci by MAIT cells has not been defined nor have the genomics and transcriptomics of the riboflavin operon. We observed robust recognition of pneumococci by MAIT cells, using both MR1-dependent and MR1-independent pathways. The pathway used was dependent on the antigen-presenting cell. The riboflavin operon was highly conserved across a range of 571 pneumococci from 39 countries, dating back to 1916, and different versions of the riboflavin operon were also identified in related Streptococcus species. These data indicate an important functional relationship between MAIT cells and pneumococci. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00221899
Volume :
217
Issue :
6
Database :
Complementary Index
Journal :
Journal of Infectious Diseases
Publication Type :
Academic Journal
Accession number :
128342870
Full Text :
https://doi.org/10.1093/infdis/jix647