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Treatment and prognosis of stage I follicular lymphoma in the modern era - does PET matter?

Authors :
Bentur, Ohad S.
Sarid, Nadav
Ram, Ron
Herishanu, Yair
Avivi, Irit
Perry, Chava
Kreiniz, Natalia
Dally, Najib
Gurion, Ronit
Raanani, Pia
Gafter-Gvili, Anat
Gutwein, Odit
Gatt, Moshe
Paltiel, Ora
Shvidel, Lev
Ganzel, Chezi
Horowitz, Netanel A.
Source :
Leukemia & Lymphoma; May2018, Vol. 59 Issue 5, p1163-1171, 9p
Publication Year :
2018

Abstract

Follicular lymphoma (FL) is the most common subtype of indolent non-Hodgkin lymphoma. Patients with stage I disease are usually treated with radiotherapy (RT). In previous studies, mostly from the pre positron emission tomography-computed tomography (PET-CT) era, the 5 year progression-free survival (PFS) and overall survival (OS) rates of stage I disease were 60-80% and 80-93%, respectively. This study retrospectively evaluated the outcome of stage I FL which was treated with involved field RT in the PET-CT era between 2002 and 2015. Ninety-one patients were enrolled. Five year PFS and OS rates were 73% and 97%, respectively. Relapse occurred in 19 (21%) patients, 74% occurring outside the radiation field. In conclusion, PET-CT staging of clinical stage I FL may contribute to the improved prognosis in patients treated with RT compared to historical cohorts, possibly due to better identification of “genuine” stage I disease. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10428194
Volume :
59
Issue :
5
Database :
Complementary Index
Journal :
Leukemia & Lymphoma
Publication Type :
Academic Journal
Accession number :
128358939
Full Text :
https://doi.org/10.1080/10428194.2017.1375102