2種類のミネラル分散配合処方でのカルシウム，マグネシウムおよび 鉄のラットにおける血漿および肝臓での吸収動態の差異 (ミネラル原料混合粉末との比較） -血漿および肝臓への吸収動態について一

To evaluate the degree and rate of absorption of orally administered dose of Ca, Mg and Fe in oil and water dispersion mineral prescriptions in comparison with mineral raw material mixing powder, plasma and liver Ca, Mg and Fe concentrations and pharmacokinetic profiles of plasma and liver Ca, Mg and Fe concentration-time were observed after administration of oil and water dispersion mineral prescriptions and mineral raw material powder. Ca, Mg and Fe contents in plasms and liver homogenate were measured by using inductively coupled plasma mass spectrometry (ICP-MS). The time course of plasma Ca concentrations indicates that AUC and Cmax of plasma Ca following oil dispersion prescription could be the most great compared with water dispersion prescription and raw material mixing powder, suggesting that Ca in oil dispersion prescription is more bioavailable from gastrointestinal tract than that in water dispersion prescription and raw material mixing powder and absorption rate of Ca in Oil dispersion prescription is more rapid than that in Water dispersion prescription and Raw material mixing powder. The time to reach peak of plasma Mg after administration of Oil dispersion prescription is less than that after administration of Water Dispersion prescription and Raw Material Mixing Powder suggesting that absorption rate of Mg in Oil dispersion prescription may be more rapid compared with other two prescriptions. The liver Ca, Mg and Fe levels in early time period following administration of these three prescriptions increase rapidly, and then decrease, suggesting that Ca, Mg and Fe absorbed in these three prescriptions are contributed to liver tissue at the beginning and then rc-contributed in body. [ABSTRACT FROM AUTHOR]