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Radical prostatectomy for clinically localized prostate cancer in patients aged 75 years or older: comparison with primary androgen deprivation therapy.
- Source :
- Aging Male; Mar2018, Vol. 21 Issue 1, p17-23, 7p
- Publication Year :
- 2018
-
Abstract
- <bold>Objective: </bold>To determine whether radical prostatetomy (RP) is suitable for prostate cancer patients with age ≥75 years in comparison to primary androgen deprivation therapy (PADT).<bold>Patients and Methods: </bold>A cohort study was conducted in clinically localized prostate cancer patients with ≥75 years of age who underwent RP or PADT at six institutions from 2005 to 2013. Patients who had less than 12 months of follow-up, or received neoadjuvant or adjuvant therapy were excluded. We compared clinical characteristics, cancer-specific and overall survivals, and post-treatment complication rates between two groups.<bold>Results: </bold>We included 92 and 99 patients in the RP and PADT groups, respectively. In survival analyses, there were no significant differences in cancer-specific and overall survivals (p = .302 and .995, respectively). The incidence of serious adverse events (cardio- or cerebrovascular event, or bone fracture) was higher in the PADT group (p = .001). Multivariable analysis showed that PADT had a worse effect on the serious adverse events (OR 10.12, p = .038).<bold>Conclusions: </bold>In selected elderly patients, RP was safe and effective for treatment of localized prostate cancer, as compared to PADT. Surgical treatment options should be considered in elderly patients with respect to life expectancy, rather than chronological age. [ABSTRACT FROM AUTHOR]
- Subjects :
- PROSTATECTOMY
PROSTATE cancer treatment
PROSTATE cancer patients
ANDROGEN drugs
ADJUVANT treatment of cancer
AGE distribution
ANTIANDROGENS
COMPARATIVE studies
LUTEINIZING hormone releasing hormone
RESEARCH methodology
MEDICAL cooperation
PROSTATE tumors
RESEARCH
SURGICAL complications
EVALUATION research
TREATMENT effectiveness
RETROSPECTIVE studies
KAPLAN-Meier estimator
Subjects
Details
- Language :
- English
- ISSN :
- 13685538
- Volume :
- 21
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Aging Male
- Publication Type :
- Academic Journal
- Accession number :
- 128864290
- Full Text :
- https://doi.org/10.1080/13685538.2017.1365122