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Filaria specific antibody response profiling in plasma from anti-retroviral naïve Loa loa microfilaraemic HIV-1 infected people.
- Source :
- BMC Infectious Diseases; 4/4/2018, Vol. 18 Issue 1, pN.PAG-N.PAG, 1p, 1 Diagram, 1 Chart, 5 Graphs
- Publication Year :
- 2018
-
Abstract
- <bold>Background: </bold>In West and Central Africa areas of endemic Loa loa infections overlap with regions of high prevalence of human immunodeficiency virus type 1 (HIV-1) infections. Because individuals in this region are exposed to filarial parasites from birth, most HIV-1 infected individuals invariably also have a history of filarial parasite infection. Since HIV-1 infection both depletes immune system and maintains it in perpetual inflammation, this can hamper Loa loa filarial parasite mediated immune modulation, leading to enhanced loaisis.<bold>Methods: </bold>In this study we have assessed in plasma from asymptomatic anti-retroviral (ARV) naïve Loa loa microfilaraemic HIV-1 infected people the filarial antibody responses specific to a filariasis composite antigen consisting of Wbgp29-BmR1-BmM14-WbSXP. The antibody responses specific to the filariasis composite antigen was determined by enzyme linked immunosorbent assay (ELISA) in plasma from ARV naïve Loa loa microfilaraemic HIV-1 infected participants. In addition the filarial antigen specific IgG antibody subclass profiles were also determined for both HIV-1 positive and negative people.<bold>Results: </bold>Both Loa loa microfilaraemic HIV-1 positive and negative individuals showed significantly higher plasma levels of IgG1 (P < 0.0001), IgG2 (P < 0.0001) and IgM (P < 0.0001) relative to amicrofilaraemic participants. A significant increase in IgE (P < 0.0001) was observed exclusively in Loa loa microfilaraemic HIV-1 infected people. In contrast there was a significant reduction in the level of IgG4 (p < 0.0001) and IgG3 (P < 0.0001) in Loa loa microfilaraemic HIV-1 infected individuals.<bold>Conclusions: </bold>Loa loa microfilaraemia in ARV naïve HIV-1 infected people through differential reduction of plasma levels of filarial antigen specific IgG3, IgG4 and a significant increase in plasma levels of filarial antigen specific IgE could diminish Loa loa mediated immune-regulation. This in effect can result to increase loaisis mediated immunopathology in antiretroviral naive HIV-1 infected people. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTIBODY formation
ANTIRETROVIRAL agents
HIV
IMMUNE system
ENZYME-linked immunosorbent assay
HIV infection complications
ANIMAL experimentation
ANTIGENS
COMPARATIVE studies
FILARIASIS
HIV infections
IMMUNOGLOBULINS
RESEARCH methodology
MEDICAL cooperation
NEMATODES
RESEARCH
RESEARCH funding
EVALUATION research
DISEASE complications
DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 14712334
- Volume :
- 18
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 128875421
- Full Text :
- https://doi.org/10.1186/s12879-018-3072-2