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Genomic Integration of HHV-6 Mimicking Viral Reactivation after Autologous Stem Cell Transplantation.
- Source :
- Mediterranean Journal of Hematology & Infectious Diseases; 2018, Vol. 10 Issue 1, p1-4, 4p
- Publication Year :
- 2018
-
Abstract
- The monitoring of Human Herpesvirus 6 (HHV-6) after allogeneic stem cell transplantation has proven to be useful in preventing life-threatening complications; however, the pathogenic role of HHV-6 after autologous transplantation is not well-characterized, although viral reactivation might be responsible for significant complications even after this type of transplant. Here we report, for the first time to our knowledge, the case of a patient with chromosomally integrated HHV-6 (ciHHV-6), presenting with high titers of HHV-6 DNA copies after autologous transplantation, mimicking HHV-6 reactivation. The presence of viral DNA in the follicle bulb confirmed the ciHHV-6 and allowed for the discontinuation of the antiviral treatment. Due to the increasing awareness of HHV-6 potential pathogenicity and the fact that ciHHV-6 is expected in 1-2% of the population, such a case might be helpful in recognizing ci HHV-6, thus avoiding unnecessary and potentially toxic antiviral therapy once the viral genomic integration is confirmed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20353006
- Volume :
- 10
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Mediterranean Journal of Hematology & Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 128933390
- Full Text :
- https://doi.org/10.4084/MJHID.2018.013