Chronic kidney disease: Pathological and functional evaluation with intravoxel incoherent motion diffusion-weighted imaging.

<bold>Background: </bold>Because chronic kidney disease (CKD) is a worldwide problem, accurate pathological and functional evaluation is required for planning treatment and follow-up. Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) can assess both capillary perfusion and tissue diffusion and may be helpful in evaluating renal function and pathology.<bold>Purpose: </bold>To evaluate functional and pathological alterations in CKD by applying IVIM-DWI.<bold>Study Type: </bold>Prospective study.<bold>Subjects: </bold>In all, 72 CKD patients who required renal biopsy and 20 healthy volunteers.<bold>Field Strength: </bold>1.5T.<bold>Assessment: </bold>All subjects underwent IVIM-DWI of the kidneys, and image analysis was performed by two radiologists. The mean values of true diffusion coefficient (D), pseudo diffusion coefficient (D*), and perfusion fraction (f) were acquired from renal parenchyma. Correlation between IVIM-DWI parameters and estimated glomerular filtration rate (eGFR), as well as pathological damage, were assessed.<bold>Statistical Tests: </bold>One-way analysis of variance (ANOVA), paired sample t-test and Spearman correlation analysis.<bold>Results: </bold>The paired sample t-test revealed that IVIM-DWI parameters were significantly lower in medulla than cortex for both patients and controls (P < 0.01). Regardless of whether eGFR was reduced, ANOVA revealed that f values of renal parenchyma were significantly lower in patients than controls (P < 0.05). Spearman correlation analysis revealed that there were positive correlations between eGFR and D (cortex, r = 0.466, P < 0.001; medulla, r = 0.491, P < 0.001), and between eGFR and f (cortex, r = 0.713, P < 0.001; medulla, r = 0.512, P < 0.001). Negative correlations were found between f and glomerular injury (cortex, r = -0.773, P < 0.001; medulla, r = -0.629, P < 0.001), and between f and tubulointerstitial lesion (cortex, r = -0.728, P < 0.001; medulla, r = -0.547, P < 0.001).<bold>Data Conclusion: </bold>IVIM-DWI might be feasible for noninvasive evaluation of renal function and pathology of CKD, especially in detection of renal insufficiency at an early stage.<bold>Level Of Evidence: </bold>1 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;47:1251-1259. [ABSTRACT FROM AUTHOR]