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Tumour-suppressive microRNA-424-5p directly targets CCNE1 as potential prognostic markers in epithelial ovarian cancer.
- Source :
- Cell Cycle; 2018, Vol. 17 Issue 3, p309-318, 10p
- Publication Year :
- 2018
-
Abstract
- An accumulated evidence supports that MicroRNAs (miRNAs) have shown a prominent role in pathological processes and different tumor onset. However, to date, the potential functional roles and molecular mechanisms by how microRNA-424-5p(miR-424-5p) affects cancer cell proliferation are greatly unclear, especially in epithelial ovarian cancer(EOC).In this study, we demonstrated that miR-424-5p was significantly down-regulated in EOC tissues and cell lines. The level of miR-424-5p was negatively correlated with tumor size, TNM stage, pathological grade, lymphatic metastasis of EOC. Restoring miR-424-5p expression in EOC cells dramatically suppressed cell proliferation and caused an accumulation of cells in G1 phase, and thus contributed to better prognosis of EOC patients. Mechanistically, miR-424-5p inhibits CCNE1 expression through targeting CCNE1 3′UTR, and subsequent arrest cell cycle in G1/G0 phase by inhibiting E2F1-pRb pathway. This study revealed functional and mechanistic links between miR-424-5p and CCNE1 in the progression of EOC and provide an important insight into that miR-424-5p may serve as a therapeutic target in EOC. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15384101
- Volume :
- 17
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Cell Cycle
- Publication Type :
- Academic Journal
- Accession number :
- 129102282
- Full Text :
- https://doi.org/10.1080/15384101.2017.1407894