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Synthesis and biological activity of arylaliphatic <italic>N</italic>-(2-aminoethyl)-<italic>N</italic>-(2-hydroxy-2-phenylethyl)carboxamides.

Authors :
Hoang, D. Q.
Borisova, E. Ya.
Borisova, N. Yu.
Asilova, N. Yu.
Kaldyrkaeva, O. S.
Arzamastsev, E. V.
Terekhova, O. A.
Afanas'eva, E. Yu.
Levitskaya, E. L.
Source :
Russian Chemical Bulletin; Jan2018, Vol. 67 Issue 1, p131-136, 6p
Publication Year :
2018

Abstract

&lt;italic&gt;N&lt;/italic&gt;-(2-Aminoethyl)-&lt;italic&gt;N&lt;/italic&gt;-(2-hydroxy-2-phenylethyl)carboxamides were synthesized from styrene oxide by ring opening with &lt;italic&gt;N&lt;/italic&gt;,&lt;italic&gt;N&lt;/italic&gt;-disubstituted ethylenediamines followed by &lt;italic&gt;N&lt;/italic&gt;-acylation. Synthesized compounds have pronounced antiarrhythmic activity and low toxicity. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10665285
Volume :
67
Issue :
1
Database :
Complementary Index
Journal :
Russian Chemical Bulletin
Publication Type :
Academic Journal
Accession number :
129180296
Full Text :
https://doi.org/10.1007/s11172-018-2048-0