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The acidic tumor microenvironment: a target for smart cancer nano-theranostics.
- Source :
- National Science Review; Mar2018, Vol. 5 Issue 2, p269-286, 18p
- Publication Year :
- 2018
-
Abstract
- The acidic tumor microenvironment (TME), which mainly results from the high glycolytic rate of tumor cells, has been characterized as a hallmark of solid tumors and found to be a pivotal factor participating in tumor progression. Recently, due to the increasing understanding of the acidic TME, it has been shown that the acidic TME could be utilized as a multifaceted target during the design of various pH-responsive nanoscale theranostic platforms for the precise diagnosis and effective treatment of cancers. In this article, we will give a focused overview on the latest progress in utilizing this characteristic acidic TME as the target of nano-theranostics to enable cancer-specific imaging and therapy.The future perspectives in the development of acidic TME-targeting nanomedicine strategies will be discussed afterwards. [ABSTRACT FROM AUTHOR]
- Subjects :
- TUMOR microenvironment
COMPANION diagnostics
CANCER treatment
Subjects
Details
- Language :
- English
- ISSN :
- 20955138
- Volume :
- 5
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- National Science Review
- Publication Type :
- Academic Journal
- Accession number :
- 129312205
- Full Text :
- https://doi.org/10.1093/nsr/nwx062