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A Difficult Case in Clinical Practice: Combined Polycythaemia Vera and Protein S Deficiency in a Patient with both Thrombotic and Bleeding Complications.
- Source :
- Journal of Clinical & Diagnostic Research; Apr2018, Vol. 12 Issue 4, p11-14, 4p
- Publication Year :
- 2018
-
Abstract
- Polycythemia Vera (PV) is a chronic myeloproliferative disorder which is characterised by a high risk of developing arterial as well as venous thromboembolic complications like deep vein thrombosis, stroke, cortical vein thrombosis and rarely acute Myocardial Infarction (MI). PV has a risk rate of major thrombosis as high as 50%. Bleeding, thrombotic, and vascular complications are the major causes of morbidity and mortality, occurring in 40 to 60% of these patients. MI with heart failure is the most common cause of death in these patients. Congenital Protein S deficiency is an autosomal dominant disease. Venous thrombosis develops in 60-80% of patients who are heterozygous for Protein S deficiency. Hereditary Protein S deficiency is a well known risk factor not only for venous thrombosis but also for arterial thrombosis including MI and stroke. However, association of Protein S deficiency with arterial thrombosis is less appreciated. Very rarely, we find all the varied thrombotic complications in one patient. We hereby present a case who had varied thrombotic presentations due to underlying polycythemia with Protein S deficiency. [ABSTRACT FROM AUTHOR]
- Subjects :
- POLYCYTHEMIA vera
PROTEIN S deficiency
THROMBOSIS
PATIENTS
Subjects
Details
- Language :
- English
- ISSN :
- 0973709X
- Volume :
- 12
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Clinical & Diagnostic Research
- Publication Type :
- Academic Journal
- Accession number :
- 129435735
- Full Text :
- https://doi.org/10.7860/JCDR/2018/31717.11438