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Adipose-derived stem-cell-implanted poly(∈-caprolactone)/chitosan scaffold improves bladder regeneration in a rat model.
- Source :
- Regenerative Medicine; Apr2018, Vol. 13 Issue 3, p331-342, 12p
- Publication Year :
- 2018
-
Abstract
- Aim: The study investigated the feasibility of seeding adipose-derived stem cells (ASCs) onto a poly(∈- caprolactone)/chitosan (PCL/CS) scaffold for bladder reconstruction using a rat model of bladder augmentation. Materials & methods: In the experimental group, the autologous ASCs were seeded onto the PCL/CS scaffold for bladder augmentation. An unseeded scaffold was used for bladder augmentation as control group. The sham group was also set. Result: 8 weeks after implantation, more densely smooth muscles were detected in the experimental group with a larger bladder capacity and more intensive blood vessels. Immunofluorescence staining demonstrated that some of the smooth muscle cells were transdifferentiated from the ASCs. Conclusion: Our findings indicated that ASC-seeded PCL/CS may be a potential scaffold for bladder tissue engineering. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17460751
- Volume :
- 13
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Regenerative Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 129468952
- Full Text :
- https://doi.org/10.2217/rme-2017-0120