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Germline V repertoires: Origin, maintenance, diversification.
- Source :
- Scandinavian Journal of Immunology; Jun2018, Vol. 87 Issue 6, p1-N.PAG, 4p
- Publication Year :
- 2018
-
Abstract
- In our view, Melvin Cohn (Scand J Immunol. 2018;87:e12640) has set out the logical guidelines towards a resolution of the very real enigma of the selectability of vertebrate germline Ig V repertoires under the current evolutionary paradigm. . ." A somatically derived repertoire scrambles this (germline VL + VH) substrate so that its specificities are lost, making it un-selectable in the germline. Consequently, evolution faced an incompatibility." It is argued here in Reply that a reverse transcriptase-based soma-to-germline process (S->G) targeting germline V segment arrays goes some considerable way to resolving fundamental contradictions on the origin, maintenance and then real-time adaptive diversification of these limited sets of V segments encoded within various V repertoire arrays. [ABSTRACT FROM AUTHOR]
- Subjects :
- GERM cells
B cells
T cells
IMMUNOGLOBULINS
VERTEBRATE genetics
Subjects
Details
- Language :
- English
- ISSN :
- 03009475
- Volume :
- 87
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Scandinavian Journal of Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 129757429
- Full Text :
- https://doi.org/10.1111/sji.12670