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CT findings are highly predictive for perforation in patients with diffuse large B-cell lymphoma involving the intestines.
- Source :
- Leukemia & Lymphoma; Aug2018, Vol. 59 Issue 8, p1878-1883, 6p
- Publication Year :
- 2018
-
Abstract
- Patients with diffuse large B-cell lymphoma (DLBCL) presenting with intestinal involvement are prone to develop perforation. Identification of those who are at high risk for this complication would enable a rational-based decision regarding preemptive surgery. Although computed tomography (CT) is widely used at diagnosis, data regarding its ability to predict intestinal perforation are scanty. We performed a retrospective single-center study, including all consecutive DLBCL patients presented with intestinal involvement, assessing predictors for perforation with an emphasis on CT-related parameters. Forty-nine patients were included, 43 (88%) underwent CT scan at diagnosis. Ten patients (20%) developed intestinal perforation. A univariate regression analysis found increased risk among patients with a concentric, transmural lesion, and a longer involved intestinal segment. In conclusion, CT scan results can define patients with DLBCL and intestinal involvement who are at risk for perforation, suggesting that a preemptive surgical resection should be considered in these cases. [ABSTRACT FROM AUTHOR]
- Subjects :
- BCL-2 proteins
LYMPHOMAS
HODGKIN'S disease
PROGNOSIS
CANCER chemotherapy
Subjects
Details
- Language :
- English
- ISSN :
- 10428194
- Volume :
- 59
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Leukemia & Lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 130504430
- Full Text :
- https://doi.org/10.1080/10428194.2017.1403023