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Trienic α-pyrone and ochratoxin derivatives from a sponge-derived fungus Aspergillus ochraceopetaliformis.

Authors :
Liu, Jing-Tang
Wu, Wei
Cao, Min-Jia
Yang, Fan
Lin, Hou-Wen
Source :
Natural Product Research; Aug2018, Vol. 32 Issue 15, p1791-1797, 7p
Publication Year :
2018

Abstract

A new trienic α-pyrone derivative asteltoxin G (1) bearing a tetrahydrofuran ring and a new ochratoxin derivative named ochratoxin A1 (5), along with seven known compounds, were isolated from a sponge-derived fungus Aspergillus ochraceopetaliformis. The compounds (1'9) were evaluated on the basis of spectroscopic analyses and comparison with those of the reported data. The new compound ochratoxin A1 (5) exhibited anti-inflammatory activity against IL-6 and TNF-α expression of the LPS-induced THP-1 cells with inhibitory rates of 74.4 and 67.7% at concentration of 10 μM, respectively. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14786419
Volume :
32
Issue :
15
Database :
Complementary Index
Journal :
Natural Product Research
Publication Type :
Academic Journal
Accession number :
130523618
Full Text :
https://doi.org/10.1080/14786419.2017.1402325