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CCND1 rs9344 polymorphism is associated with the risk of hepatocellular carcinoma in Caucasian population.
- Source :
- Journal of Cancer Research & Therapeutics; 2018 Supplement, Vol. 14, p516-518, 3p
- Publication Year :
- 2018
-
Abstract
- <bold>Aims: </bold>Some studies investigated the association between CCND1 rs9344 polymorphism and hepatocellular carcinoma (HCC) risk. However, the results were inconclusive. Thus, we did a meta-analysis to determine this relationship.<bold>Materials and Methods: </bold>Relevant studies were systematically searched using the PubMed, CNKI, and EMBASE databases. The strength of the association was calculated with the odds ratio (OR) and respective 95% confidence intervals (Cis).<bold>Results: </bold>We investigated the association between CCND1 rs9344 polymorphism and HCC risk in the dominant models. The result of this meta-analysis showed that CCND1 rs9344 polymorphism did not significantly associated with HCC risk (OR = 1.09; 95% CI 0.88-1.34). In the stratified analysis by ethnicity, we found that this polymorphism was significantly associated with HCC risk in Caucasians (OR = 1.55; 95% CI, 1.05-2.29). However, we did not find any significant association between this polymorphism and HCC risk in Asians (OR = 0.91; 95% CI, 0.71-1.18).<bold>Conclusions: </bold>This meta-analysis suggested that CCND1 rs9344 polymorphism might be associated with the risk of HCC among Caucasians. [ABSTRACT FROM AUTHOR]
- Subjects :
- GENETIC polymorphisms
LIVER cancer
ODDS ratio
CONFIDENCE intervals
ALLELES
ASIANS
COMPARATIVE studies
DISEASE susceptibility
GENETIC techniques
HEPATOCELLULAR carcinoma
LIVER tumors
RESEARCH methodology
MEDICAL cooperation
META-analysis
PROTEINS
RESEARCH
RISK assessment
WHITE people
EVALUATION research
CASE-control method
PUBLICATION bias
Subjects
Details
- Language :
- English
- ISSN :
- 09731482
- Volume :
- 14
- Database :
- Complementary Index
- Journal :
- Journal of Cancer Research & Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 130546872
- Full Text :
- https://doi.org/10.4103/0973-1482.203598