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Effects of once-monthly minodronate versus risedronate in osteoporosis patients with rheumatoid arthritis: a 12-month randomized head-to-head comparison.
- Source :
- Osteoporosis International; Jul2018, Vol. 29 Issue 7, p1637-1642, 6p, 1 Diagram, 2 Charts, 2 Graphs
- Publication Year :
- 2018
-
Abstract
- Summary: A head-to-head comparison of once-monthly oral bisphosphonates minodronate (MIN) and risedronate (RIS) in patients with rheumatoid arthritis (RA) demonstrated that MIN has the same effect as RIS on increase in bone mineral density (BMD) and a stronger effect on inhibition of bone resorption than RIS, suggesting that MIN is a promising treatment option for osteoporosis patients with RA.Introduction: To evaluate the effect of once-monthly oral MIN in patients with RA, a prospective, randomized, open-label, head-to-head comparison with once-monthly oral RIS was conducted.Methods: A total of 83 patients with RA were randomly assigned to either once-monthly oral MIN 50 mg (n = 42) or once-monthly oral RIS 75 mg (n = 41). Serial BMD and bone turnover markers were measured and compared between the treatment groups.Results: BMD (lumbar spine, total hip, femoral neck) increased significantly after 12 months of treatment with MIN (3.8, 2.0, and 2.2%, respectively, P < 0.05) and RIS (3.6, 1.9, and 1.9%, respectively, P < 0.05). There were no significant differences between the treatment groups. Percent changes of bone turnover markers from baseline to 12 months in the MIN group were significantly greater than those in the RIS group (TRACP-5b: − 36.3 vs − 19.3%, P < 0.05; NTX: − 27.1 vs − 17.3%, P < 0.05; BAP: −30.2 vs −19.4%, P < 0.05).Conclusions: The present study of RA patients demonstrated that MIN has the same effect as RIS on increase in BMD and a stronger effect on inhibition of bone resorption than RIS. The results suggest that MIN is a promising treatment option for osteoporosis patients with RA. [ABSTRACT FROM AUTHOR]
- Subjects :
- RISEDRONATE
OSTEOPOROSIS
RHEUMATOID arthritis treatment
PATIENTS
THERAPEUTICS
HIP joint physiology
SPINE physiology
FEMUR neck
BONE remodeling
BIOMARKERS
BONE resorption
DIPHOSPHONATES
LONGITUDINAL method
ORAL drug administration
RHEUMATOID arthritis
BONE density
RANDOMIZED controlled trials
TREATMENT duration
DISEASE complications
PHYSIOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 0937941X
- Volume :
- 29
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Osteoporosis International
- Publication Type :
- Academic Journal
- Accession number :
- 130553358
- Full Text :
- https://doi.org/10.1007/s00198-018-4494-9